The Queen of Pop threaten to cancel concert in Santiago, Chile when smokers caught her attention. Apparently, smoking is a big no for the diva. 

Madonna yelled at fans during her soundcheck, preparing for her concert when cigarette smokers jeopardize her health. 

The 54 year-old told the smokers "No Smoking!, If you're going to smoke cigarettes, I'm not doing a show," according to THR.

The singer in the mist of her  MDNA tour , which has sold over $228.4 million in tickets. Billboard rated her recent tour the highest-grossing tour with 72 sold out concerts.

Madonna added "You don't care about me? I don't care about you. All right? I'm not kidding, I can't sing if you smoke.. You're looking right at me and smoking cigarettes, like I'm a stupid F*&ing idiot."

The Queen of Pop has sold over 300 million records world wide, and is best selling female artist of all times.